Method of treating cancer with a tumor cell line having modified cytokine expression
US6350445B1 · kind B1 · utility
Assignee
Inventors
Key dates
| Filing date | Sep 1, 1999 |
| Grant date | Feb 26, 2002 |
| Priority date | — |
| Expiry date | Sep 1, 2019 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2501/33
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention provides a method of treating cancer comprising (a) obtaining a tumor cell line, (b) modifying the tumor cell line to render it capable of producing an increased level of a cytokine relative to the unmodified tumor cell line, and (c) administering the tumor cell line to a mammalian host having at least one tumor that is the same type of tumor as that from which the tumor cell line was obtained, wherein the tumor cell line is allogeneic and is not MHC-matched to the host. The present invention also provides a pancreatic tumor cell line, a method and medium for obtaining such a tumor cell line, and a composition comprised of cells of a purified pancreatic tumor cell line.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.