Reagents and methods useful for detecting diseases of the prostate

US6350583B1 · kind B1 · utility

Assignee

• Abbott Laboratories · US

Inventors

• Maurice Cohen · Miami, US
• Tracey Colpitts · Round Lake, US
• Paula Friedman · Deerfield, US
• Edward Granados · Vernon Hills, US
• Michael Klass · Libertyville, US
• John Russell · Pleasant Prairie, US
• Stephen D. Stroupe · Libertyville, US

Key dates

• Filing date: May 8, 2000
• Grant date: Feb 26, 2002
• Expiry date: May 8, 2020

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N33/57434
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

A set of contiguous and partially overlapping RNA sequences and polypeptides encoded thereby, designated as PS190 and transcribed from prostate tissue is described. These sequences are useful for the detecting, diagnosing, staging, monitoring, prognosticating, preventing or treating, or determining the predisposition of an individual to diseases and conditions of the prostate, such as prostate cancer. Also provided are antibodies which specifically bind to PS190-encoded polypeptide or protein, and agonists or inhibitors which prevent action of the tissue-specific PS190 polypeptide, which molecules are useful for the therapeutic treatment of prostate diseases, tumors or metastases.