Thrombin inhibitors
US6350745B1 · kind B1 · utility
1Cited by
8References
8Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jun 2, 2000 |
| Grant date | Feb 26, 2002 |
| Priority date | — |
| Expiry date | Jun 2, 2020 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P43/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Compounds of the invention, useful as thrombin inhibitors and having therapeutic value in for example, preventing coronary artery disease, have the following structure: or a pharmaceutically acceptable salt thereof, whereinA is whereinY1 and Y2 are independentlyhydrogen,C1-4 alkyl,C1-4 alkoxy,FuHvC(CH2)0-1 O—, wherein u and v are either 1 or 2, provided that when u is 1, v is 2, and when u is 2, v is 1,C3-7 cycloalkyl,thio C1-4 alkyl,C1-4 sulfinylalkyl,C1-4 sulfonylalkyl,halogencyano, ortrifluoromethyl, andwherein b is 0 or 1.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.