2-Substituted-4-substituted-1,3-dioxolanes and use thereof
US6350753B1 · kind B1 · utility
27Cited by
21References
39Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Sep 30, 1998 |
| Grant date | Feb 26, 2002 |
| Priority date | — |
| Expiry date | Sep 30, 2018 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D473/40
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Nucleoside analogues containing a 1,3-dioxolane structure are suitable antiviral agents, particulary for the treatment of the HIV infections in mammals, especially humans. Examples of the nucleoside analogues include:cis-2-acetoxymethyl-4-(thymin-1′-yl)-1,3,-dioxolane,cis-2-hydroxymethyl-4-(thymin-1′-yl)-1,3-dioxolane,cis-2-benzoyloxymethyl-4-(cytosin-1′-yl)-1,3-dioxolane, andcis-2-hydroxymethyl-4-(cytosin-1′-yl)-1,3-dioxolane.These compounds can be in the form of their racemates or their separate enantiomers.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.