Substituted piperidines as melanocortin-4 receptor agonists

US6350760B1 · kind B1 · utility

Assignee

• MERCK & CO., INC. · US

Inventors

• Raman K. Bakshi · Edison, US
• Khaled Barakat · Brooklyn, US
• Ravi Nargund · East Brunswick Township, US
• Brenda Palucki · Fryeburg, US
• Arthur A. Patchett · Westfield, US
• Iyassu Sebhat · Jersey City, US
• Zhixiong Ye · Princeton, US
• Leonardus H. T. Van Der Ploeg · Newton, US

Key dates

• Filing date: Jun 1, 2000
• Grant date: Feb 26, 2002
• Expiry date: Jun 1, 2020

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D471/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Certain novel substituted piperidine compounds are agonists of the human melanocortin receptor(s) and, in particular, are selective agonists of the human melanocortin-4 receptor (MC-4R). They are therefore useful for the treatment, control, or prevention of diseases and disorders responsive to the activation of MC-4R, such as obesity, diabetes, sexual dysfunction, including erectile dysfunction and female sexual dysfunction. Also provided are methods of treating sexual dysfunction with a compound that is a selective agonist of MC-4R over any other human melanocortin receptor.