Description anti-mitotic agents which inhibit tubulin polymerization

US6350777B2 · kind B2 · utility

Assignees

• Baylor University · US
• The Arizona Disease Control Research Commission · US

Inventors

• Kevin G. Pinney · Woodway, US
• George R. Pettit · Paradise Valley, US
• Vani P. Mocharla · Los Angeles, US
• Maria Mejia · Evanston, US
• Anupama Shirali · Pune, IN

Key dates

• Filing date: Dec 15, 2000
• Grant date: Feb 26, 2002
• Expiry date: Dec 15, 2020

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C2602/10
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Methoxy and ethoxy substituted 3-aroyl-2-arylbenzo[b]thiophenes and benzo[b]thiophene analogues are described for use in inhibiting tubulin polymerization. The compounds' use for treating tumor cells is also described.Additional aspects described here are certain diaryl ether benzo[b]thiophene derivatives. Also described are particular analogs derived from dihydronaphthalene which have proven particularly effective. Certain new benzofuran analogs are described, as well as certain sulfur oxide benzo[b]thiophene analogs.Important compounds described herein include the first nitrogen-containing derivatives of combretastatin. These include nitro, amino and azide combrdtastatin derivatives.