Conjugated peptide nucleic acids having enhanced cellular uptake
US6350853B1 · kind B1 · utility
31Cited by
4References
8Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Sep 23, 1999 |
| Grant date | Feb 26, 2002 |
| Priority date | — |
| Expiry date | Sep 23, 2019 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2310/3181
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Peptide nucleic acids conjugated to lipophilic groups and incorporated into liposomes exhibit enhanced cellular uptake and distribution. Cellular uptake and distribution of peptide nucleic acids also increases with the introduction of an amino acid side chain into the backbone of peptide nucleic acids. Methods of modulating cellular uptake and methods for treating animals are provided. The peptide nucleic acids of the invention comprise naturally-occurring nucleobases and non-naturally-occurring nucleobases attached to a polyamide backbone.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.