Intermediates for the synthesis of epothilones and methods for their preparation

US6350878B1 · kind B1 · utility

Assignee

• Novartis AG · CH

Inventors

• Karl-Heinz Altmann · Reinach, CH
• Armin Bauer · Pocking, DE
• Dieter Schinzer · Braunschweig, DE

Key dates

• Filing date: Nov 17, 2000
• Grant date: Feb 26, 2002
• Expiry date: Nov 17, 2020

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02P20/55
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The invention relates to a method of synthesis for a compound of formula (I), wherein R is a heterocyclyl moiety and X1, X2, X3 and X4 are, independently of each other, protecting groups, which is appropriate for the synthesis of epothilone B and desoxyepothione B.