Vitamin D receptor ablated mice
US6350932B1 · kind B1 · utility
1Cited by
3References
10Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Aug 28, 1998 |
| Grant date | Feb 26, 2002 |
| Priority date | — |
| Expiry date | Aug 28, 2018 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2333/70567
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
A transgenic mouse containing disruptions in both vitamin D alleles and lacking vitamin D receptor activity is described. The transgenic mouse displays perioral and periorbital alopecia, hypocalcemia, hypophosphatemia, and bone demineralization. The transgenic mouse is useful for screening treatments for a number of conditions associated with vitamin D receptor related disorders including skin disorders, immune system disorders, and proliferative disorders.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.