Saponin preparations and use thereof in iscoms

US6352697B1 · kind B1 · utility

Assignee

• Iscotec A.B. · SE

Inventors

• John C. Cox · Gisborne, AU
• Alan Robert Coulter · Melbourne, AU
• Bror Morein · Uppsala, SE
• Karin Lovgren-Bengtsson · Stockholm, SE
• Bo Sundquist · Uppsala, SE

Key dates

• Filing date: Feb 22, 1999
• Grant date: Mar 5, 2002
• Expiry date: Feb 22, 2019

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P37/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Saponin preparations based on defined compositions of purified saponin fractions derived from the bark of Quillaja saponaria Molina are disclosed. The saponin preparations are useful in immunostimulating complex (iscom) matrices. The saponin preparations, and iscom matrices prepared using them, have particular activity as adjuvants.