Bone morphogenetic proteins and their use in bone growth

US6352972B1 · kind B1 · utility

Inventors

• Marcel E. Nimni · Santa Monica, US
• Frederick L. Hall · Santa Monica, US
• Lingtau Wu · Arcadia, US
• Bo Han · Los Angeles, US
• Edwin C. Shors · Rancho Palos Verdes, US

Key dates

• Filing date: Jun 3, 1997
• Grant date: Mar 5, 2002
• Expiry date: Jun 3, 2017

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02A50/30
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A bone morphogenetic fusion protein and a method of preparation of the bone morphogenetic fusion protein. The bone morphogenetic fusion protein comprises a purification tag and a bone morphogenetic active fragment. A method of preparing bone morphogenetic fusion protein comprises purifying and renaturing bone morphogenetic protein to provide an active bone morphogenetic fusion protein preparation. Methods of use of the bone morphogenetic fusion protein are also provided.