Spiro-quinuclidine derivatives, their preparation and use

US6352995B1 · kind B1 · utility

Assignee

• Neurosearch A/S · DK

Inventors

• Dan Peters · Arlöv, SE
• Gunnar M. Olsen · Smørumnedre, DK
• Simon Feldbaek Nielsen · Rang Taché Est, DK
• Elsebet Nielsen · Rang Taché Est, DK

Key dates

• Filing date: Oct 14, 1999
• Grant date: Mar 5, 2002
• Expiry date: Oct 14, 2019

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P29/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention discloses compounds of formula (I), or a pharmaceutically acceptable salt thereof; wherein n is 1 or 2 or 3, A is —O—, —S—, —CH—, —O—CH2—, or —CH2—O—; B is —O—, —S—, —CH2—, —0—CH2—, or —CH2—O—; and C is N, or —CR1—; D is N, or —CR2—; E is N, or —CR3—; and F is N, or —CR4—; wherein R1, R2, R3 and R4 each independently are selected from the group consisting of alkyl, cycloalkyl, cycloalkylalkyl, alkenyl, alkynyl, alkoxy, cycloalkoxy, thioalkoxy, thiocycloalkoxy, methylenedioxy, aryloxy, halogen, CF3, OCF3, CN, amino, nitro, aryl and a monocyclic 5 to 6 membered heteroaryl group. The compounds of the invention are useful for the treatment of disorders or diseases responsive to the activity of nicotinic ACh receptor modulators.