Human N-type calcium channel isoform
US6353091B1 · kind B1 · utility
Assignee
Inventors
Key dates
| Filing date | Mar 12, 1999 |
| Grant date | Mar 5, 2002 |
| Priority date | — |
| Expiry date | Mar 12, 2019 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2800/28
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention pertains to a human N-type calcium channel isoform, h&agr;1B+SFVG, which is involved in central nervous system signaling, and nucleic acids relating thereto. The present invention also includes fragments and biologically functional variants of the human h&agr;1B+SFVG channel. Also included are human N-type calcium channel h&agr;1B+SFVG subunit inhibitors which inhibit human N-type calcium channel h&agr;1B+SFVG subunit activity by inhibiting the expression or function of human N-type calcium channel h&agr;1B+SFVG subunit. The invention further relates to methods of using such nucleic acids, polypeptides, and inhibitors in the treatment and/or diagnosis of disease, such as in methods for treating stroke, pain, e.g., neuropathic pain, and traumatic brain injury.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.