Patent · US Expired

Chimeric mammals with human hematopoietic cells

US6353150B1 · kind B1 · utility

55Cited by

0References

5Claims

0Family size

Assignee

HSC Research and Development Limited Partnership · CA

Inventors

John Dick · Toronto, CA
Douglas E. Williams · Redmond, US
Tsvee Lapidot · Nes Ziona, IL

Key dates

Filing date	Nov 22, 1991
Grant date	Mar 5, 2002
Priority date	—
Expiry date	Nov 22, 2011

Classification

Technology area (CPC A)Human Necessities
CPC primaryA01K2217/05
WIPO fieldBiotechnology
WIPO sectorChemistry

Abstract

There is disclosed a chimeric mammal having a stable bone marrow graft of human hematopoietic cells capable of differentiating into multiple lineages of human mature cells, wherein at least 30% of the hematopoietic cells in the mammal's bone marrow are of human origin. The inventive method comprises sublethally irradiating an immunodeficient mammal, infusing human hematopoietic cells into the mammal and administering an effective amount of human mast cell growth factor (MGF) and a human granulocyte macrophage colony stimulating factor/interleukin-3 fusion protein (GM-CSF/IL-3 FP) to promote engraftment of human cells within the chimeric mammal's bone marrow.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.