Methods for using the obese gene and its gene product to stimulate hematopoietic development
US6355237B1 · kind B1 · utility
Assignee
Inventors
Key dates
| Filing date | Mar 20, 1996 |
| Grant date | Mar 12, 2002 |
| Priority date | — |
| Expiry date | Mar 20, 2016 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2506/02
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to methods for using various forms of a novel receptor expressed by hematopoietic and endothelial cells. An additional variant form of this receptor has been detected in brain cells and shown to bind to the obese gene product, leptin. Therefore, leptin may be used to stimulate the growth and development of receptor-positive hematopoietic and endothelial cells in vitro and in vivo. In addition, this receptor is selectively expressed in hematopoietic progenitor cells with long-term repopulating potential. Thus, agents that specifically bind to this receptor may be used to identify and isolate progenitor cells for a variety of clinical applications.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.