Aminoalkyl glucosamine phosphate compounds and their use as adjuvants and immunoeffectors
US6355257B1 · kind B1 · utility
57Cited by
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6Claims
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Key dates
| Filing date | May 7, 1998 |
| Grant date | Mar 12, 2002 |
| Priority date | — |
| Expiry date | May 7, 2018 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P37/04
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Aminoalkyl glucosamine phosphate compounds that are adjuvants and immunoeffectors are described and claimed. The compounds have a 2-deoxy-2-amino glucose in glycosidic linkage with an aminoalkyl (aglycon) group. Compounds are phosphorylated at the 4 or 6 carbon on the glucosamine ring and comprise three 3-alkanoyloxyalkanoyl residues. The compounds augment antibody production in immunized animals as well as stimulate cytokine production and activate macrophages. Methods for using the compounds as adjuvants and immunoeffectors are also disclosed.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.