Genes for the biosynthesis of epothilones
US6355459B1 · kind B1 · utility
9Cited by
10References
115Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | May 10, 2000 |
| Grant date | Mar 12, 2002 |
| Priority date | — |
| Expiry date | May 10, 2020 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12P17/181
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Nucleic acid molecules are isolated from Sorangium cellulosum that encode polypeptides necessary for the biosynthesis of epothilone. Disclosed are methods for the production of epothilone in recombinant hosts transformed with the genes of the invention. In this manner, epothilone can be produced in quantities large enough to enable their purification and use in pharmaceutical formulations such as those for the treatment of cancer.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.