Cyclic boroproline compounds
US6355614B1 · kind B1 · utility
52Cited by
28References
8Claims
0Family size
Assignee
Inventor
Key dates
| Filing date | May 14, 1999 |
| Grant date | Mar 12, 2002 |
| Priority date | — |
| Expiry date | May 14, 2019 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07F5/04
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Substantially pure preparations of cyclic boroProline compounds that bind, in cyclic or linear form, to CD26 are provided. Methods for using the cyclic compounds to stimulate the activation and/or proliferation of immune cells to achieve preselected normal in vivo levels of these cells also are provided. Evidence of the oral bioavailability and activity of a preferred cyclic compound, valine-prolineboronic acid (ValboroPro), also is provided.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.