Caspase inhibitors and the use thereof
US6355618B1 · kind B1 · utility
18Cited by
14References
42Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Apr 7, 2000 |
| Grant date | Mar 12, 2002 |
| Priority date | — |
| Expiry date | Apr 7, 2020 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C2601/14
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention is directed to novel dipeptide thereof, represented by the general Formula I: where R1-R3, X and Y are defined herein. The present invention also relates to the discovery that compounds having Formula I are potent inhibitors of caspases and apoptotic cell death. Therefore, the inhibitors of this invention can retard or block cell death in a variety of clinical conditions in which the loss of cells, tissues or entire organs occurs.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.