Coumarin derivatives, methods of preparation and application as medicines

US6355658B1 · kind B1 · utility

Assignee

• CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE · FR

Inventors

• Michele Reboud-Ravaux · Paris, FR
• Lionel Pochet · Gembloux, BE
• Caroline Doucet · Paris, FR
• Bernard Pirotte · Liège, BE
• Nicole Boggetto · Yerres, FR
• Jacques Delarge · Dolembreux, BE

Key dates

• Filing date: Feb 1, 2000
• Grant date: Mar 12, 2002
• Expiry date: Feb 1, 2020

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D405/12
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention concerns compounds of general formula (I) in which: X, X′ and X″ independently of each other represent O or S; Y represents O, S, NH or NHS; R3 represents in particular a cycloalkyl group; R5, R6, R7 and R8 mutually identical or different, represent in particular hydrogen; a halogen atom. Said compounds can be used as active substances of medicines as inhibitors of protease.