Isolated p27 protein
US6355774B1 · kind B1 · utility
1Cited by
1References
4Claims
0Family size
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Inventors
Key dates
| Filing date | May 9, 1997 |
| Grant date | Mar 12, 2002 |
| Priority date | — |
| Expiry date | May 9, 2017 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
An isolated protein designated p27 is disclosed. The p27 protein has an apparent molecular weight of about 27 kD, and is capable of binding to and inhibiting the activation of a cyclin E-Cdk2 complex. A nucleic acid sequence encoding p27 protein is disclosed, as well as a method for producing p27 in cultured cells. In vitro assays for discovering agents which affect the activity of p27 are also provided. Methods of diagnosing and treating hypoproliferative disorders are provided.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.