Cytokine designated 4-1BB ligand antibodies and human receptor that binds thereto
US6355779B1 · kind B1 · utility
104Cited by
4References
4Claims
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Key dates
| Filing date | Sep 10, 1998 |
| Grant date | Mar 12, 2002 |
| Priority date | — |
| Expiry date | Sep 10, 2018 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2319/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Novel 4-1BB ligand (4-1BB-L) polypeptides and a human cell surface receptor designated 4-1BB that binds 4-1BB-L are provided. Isolated 4-1BB-L-encoding and human 4-1BB-encoding DNA sequences, recombinant expression vectors comprising the isolated DNA sequences, and host cells transformed with the recombinant expression vectors are disclosed, along with methods for producing the novel polypeptides by cultivating such transformed host cells. Soluble forms of the 4-1BB-L or 4-1BB polypeptides are derived from the extracellular domains thereof.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.