Efficient synthetic routes for the preparation of rhinovirus protease inhibitors and key intermediates

US6355807B1 · kind B1 · utility

Assignee

• Agouron Pharmaceuticals, Inc. · US

Inventors

• Qingping Tian · San Diego, US
• Naresh Nayyar · San Diego, US
• Srinivasan Babu · San Diego, US
• Junhua Tao · San Diego, US
• Terence Moran · San Diego, US
• Raymond Dagnino, Jr. · El Cajon, US
• Lennert J. Mitchell, Jr. · Chula Vista, US
• Travis Remarchuk · South San Francisco, US
• Michael Joseph Melnick · Portage, US
• Steven Bender · Oceanside, US

Key dates

• Filing date: Aug 23, 2000
• Grant date: Mar 12, 2002
• Expiry date: Aug 23, 2020

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07B2200/07
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Efficient synthetic routes for the preparation of rhinovirus protease inhibitors of formula I, as well as key intermediates useful in those synthetic routes. These compounds of formula I, as well as pharmaceutical compositions that contain these compounds, are suitable for treating patients or hosts infected with one or more picornaviruses