Target cell-specific non-viral vectors for inserting genes into cells, pharmaceutical compositions comprising such vectors and their use

US6358524B1 · kind B1 · utility

Assignee

• Aventis Pharma Deutschland GmbH · DE

Inventors

• Hans-Harald Sedlacek · Marburg, DE
• Hans-Dieter Klenk · Linden, DE
• Thomas Kissel · Rochester, US
• Rolf Muller · Marburg, DE

Key dates

• Filing date: Mar 29, 1999
• Grant date: Mar 19, 2002
• Expiry date: Mar 29, 2019

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N15/87
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Target cell-specific, non-viral vectors for inserting genes into cells, pharmaceuticals composition comprising such vectors, and methods of their use. Target cell-specific, non-viral vectors for inserting at least one gene into cells of an organism, comprising a complex comprising the following components:a) a non-viral carrier for the gene to be inserted,b) a ligand which can bind specifically to the desired target cell,c) a fusion protein for the penetration of the vector into the cytoplasm of the target cell, andd) the gene to be introducedare disclosed. Vectors of this nature are used, for example, in gene therapy.