Osteocyte cell lines
US6358737B1 · kind B1 · utility
Assignee
Inventors
Key dates
| Filing date | Sep 11, 1998 |
| Grant date | Mar 19, 2002 |
| Priority date | — |
| Expiry date | Sep 11, 2018 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2710/16222
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The present invention relates to a method of producing osteocyte cell line in various stages of differentiation. Such cell line remains stable after more than 20 passages. The osteocyte has a stellate shape with dendritic processes and expresses high level of osteocalcin. More specifically, it provides a method of production for cultured osteocytes of various differentiation stages. Furthermore, it relates to osteocyte cell line, and more specifically cultured osteocyte. The invention also relates to a method for the production of monoclonal antibodies using such cultured osteocytes and further relates to hybridomas and monoclonal antibodies which recognize an osteocyte-specific antigen. Finally, the invention relates to a method of screening for modification factors and binding factors for osteocytes.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.