Patent · US Expired

PDGF receptor kinase inhibitory compounds, their preparation, purification and pharmaceutical compositions including same

US6358954B1 · kind B1 · utility

4Cited by

2References

20Claims

0Family size

Assignee

YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD. · IL

Inventors

Alexander Levitzki · Melrose, US
Aviv Gazit · Jerusalem, IL
Shmuel Banai · Jerusalem, IL
S. David Gertz · Jerusalem, IL
Gershon Golomb · Beer Sheva, IL
Frank D. Boehmer · Vacha, DE
Johannes Waltenberger · Ulm, DE

Key dates

Filing date	Nov 9, 1999
Grant date	Mar 19, 2002
Priority date	—
Expiry date	Nov 9, 2019

Classification

Technology area (CPC A)Human Necessities
CPC primaryA61P43/00
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

An isometric enriched tyrphostin of a general formula: wherein, for Compound I, the tyrphostin is enriched either for R6 at position 6 or for R6 at position 7, or, for Compound II, the tyrphostin is enriched either for R6 at position 6 or for R6 at position 8. Further disclosed are pharmaceutical compositons containing the isometric enriched tyrphostin and methods of using same to treat cell proliferative diseases.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.