Ergoline amine derivatives with blood pressure lowering effect

US6358967B1 · kind B1 · utility

Assignee

• CyBio Screening GmbH · DE

Inventors

• Ralf Wyrwa · Kahla, DE
• Albert Haertl · Jena, DE
• Erika Glusa · Erfurt, DE
• Susanne Grabley · Königstein, DE
• Ralf Thiericke · Jena, DE

Key dates

• Filing date: Apr 19, 2001
• Grant date: Mar 19, 2002
• Expiry date: Apr 19, 2021

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07F17/02
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The invention relates to novel derivatives of ergoline of the general formula 1 in which R1 together with the two adjacent N atoms is the residue of a diamine and R4 together with the two adjacent carbonyl groups is the residue of a dicarboxylic acid. R2, R3, R6, R7, R8 can be H or an organic radical. R7 and R8 are H or together are a bond.The compounds show a strong antihypertensive effect. These effects moreover occur after intravenous and enteral administration even at dosages in the region of a few &mgr;g/kg (body weight). The compounds can accordingly be used as pharmaceuticals for hypertensive diseases in human medicine.