N-substituted urea inhibitors of farnesyl-protein transferase
US6358968B1 · kind B1 · utility
10Cited by
3References
13Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jan 14, 2000 |
| Grant date | Mar 19, 2002 |
| Priority date | — |
| Expiry date | Jan 14, 2020 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P35/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Novel halo-N-substituted urea compounds and pharmaceutical compositions are disclosed which are inhibitors of the enzyme, farnesyl protein transferase. Also disclosed is a method of inhibiting Ras function and therefore inhibiting the abnormal growth of cells. The method comprises administering the novel halo-N-substituted urea compound to a biological system. In particular, the method inhibits the abnormal growth of cells in a mammals such as a human.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.