Styryl sulfone anticancer agents

US6359013B1 · kind B1 · utility

Assignee

• Temple University-Of The Commonwealth System of Higher Education · US

Inventors

• E. Premkumar Reddy · Villanova, US
• M. V. Ramana Reddy · Upper Darby, US

Key dates

• Filing date: Mar 24, 2000
• Grant date: Mar 19, 2002
• Expiry date: Mar 24, 2020

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C317/14
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Styryl sulfone compounds of the invention selectively inhibit proliferation of tumor cells, and induce apoptosis of such tumor cells, while sparing normal cells. The compounds, which are useful in the treatment of cancer, have the formula II: whereinn is zero or one;R1 is selected from the group consisting of hydrogen, chlorine, fluorine and bromine;R2 is selected from the group consisting of hydrogen, chlorine, fluorine, bromine, methyl and methoxy; andR3 is selected from the group consisting of hydrogen, chlorine and fluorine; provided,R2 may not be methyl or methoxy when R1 and R3 are both hydrogen and n is zero or one; andR1, R2 and R3 may not all be hydrogen when n is one, or the formula III: whereinR1 is selected from the group consisting of hydrogen, chlorine, fluorine and bromine or the formula IV: whereinR1 is selected from the group consisting of fluorine and bromine, and R2 is selected from the group consisting of 2-chlorophenyl, 4-chlorophenyl, 4-fluorophenyl and 2-nitrophenyl.