Compositions and methods for the treatment and diagnosis of cardiovascular disease
US6359194B1 · kind B1 · utility
1Cited by
7References
11Claims
0Family size
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Key dates
| Filing date | Apr 8, 1999 |
| Grant date | Mar 19, 2002 |
| Priority date | — |
| Expiry date | Apr 8, 2019 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention is based on the generation and phenotypic characterization of transgenic knockout homozygous rchd534 mutant mice which display characteristic cardiovascular disease symptoms. Such transgenic knockout homozygous rchd534 mutant mice are useful models for the analysis and characterization of rchd534 protein involvement in development and homeostasis of the cardiovascular system and tissue-specific regulation of the TGF-&bgr; signaling pathways. Such transgenic mice may be used for screening compounds that may potentially useful for treating or preventing cardiovascular disease.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.