Method of enhancing expression of MHC class I molecules bearing endogenous peptides
US6361770B1 · kind B1 · utility
2Cited by
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10Claims
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Key dates
| Filing date | Jul 21, 1997 |
| Grant date | Mar 26, 2002 |
| Priority date | — |
| Expiry date | Jul 21, 2017 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A method of enhancing expression of MHC Class I molecules bearing endogenous peptides on the surface of a target cell expressing low or nondetectable levels of MHC Class I molecules and expressing low or nondetectable levels of TAP-1 and TAP-2 transporter proteins comprising: introducing into the target cell a nucleic acid molecule comprising a sequence encoding TAP-1 or TAP-2 under control of a suitable promoter; and expressing TAP-1 or TAP-2 in the target cell under suitable conditions, thereby enhancing processing and presentation of MHC Class I molecules bearing endogenous peptides.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.