Co-administration of interleukin-3 mutant polypeptides with CSF'S for multi-lineage hematopoietic cell production

US6361976B1 · kind B1 · utility

Inventors

• S. Christopher Bauer · New Haven, US
• Mark Allen Abrams · Chesterfield, US
• Sarah Ruth Braford-Goldberg · Chesterfield, US
• Maire Helena Caparon · Chesterfield, US
• Alan Michael Easton · Maryland Heights, US
• Barbara Kure Klein · Eureka, US
• John McKearn · Park Hills, US
• Peter O. Olins · Park Hills, US
• Kumnan Paik · Wilmette, US
• John Warren Thomas · Eureka, US

Key dates

• Filing date: Jun 6, 1995
• Grant date: Mar 26, 2002
• Expiry date: Jun 6, 2015

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2319/02
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to human interleukin-3 (hIL-3) variant or mutant proteins (muteins) functionally co-administered with a other colony stimulating factors (CSF), cytokines, lymphokines, interleukins, hematopoietic growth factors or IL-3 variants.