Benzylglycosylamides as inhibitors of smooth muscle cell proliferation

US6362170B1 · kind B1 · utility

Assignee

• Amerimas Home Products, Inc. · US

Inventors

• Robert E. McDevitt · Somerville, US
• Folake O. Adebayo · Cranbury, US

Key dates

• Filing date: Nov 22, 1999
• Grant date: Mar 26, 2002
• Expiry date: Nov 22, 2019

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07H13/10
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

This invention provides smooth muscle cell proliferation inhibitors of formula I having the structure whereinY is C or N;where n is 0-3;X is R1, and R2 are each independently, hydrogen, alkyl of 1 to 6 carbon atoms, halo, acetyl, phenyl, CF3, CN, OH, NO2, NH2, alkoxy of 1 to 6 carbon atoms, or alkoxynitrile of 1 to 6 carbon atoms;R3 is hydrogen, acylamide of 2 to 6 carbon atoms or alkoxy of 1 to 6 carbon atoms;R4, R5, R6, R7, and R8 are each, independently, acyl of 1 to 6 carbon atoms, benzyl substituted with R1, and R2; or benzoyl substituted with R1 and R2;R9 and R10 are each, independently, acyl of 1 to 6 carbon atoms, or the R9 and R10 groups on the 4′ and 6′ positions of the maltose may be taken together to form a cyclic acetal which may be substituted with alkyl of 1 to 6 carbon atoms, two alkyl groups each having 1 to 6 carbon atoms, pyridine substituted with R1, phenyl substituted with R1, benzyl substituted with R1, 2-phenylethyl substituted with R1, or 3-phenylpropyl substituted with R1;or a pharmaceutically acceptable salt thereof.