Aminoaklanoyl-linked conjugates of 2′,5′-oligoadenylate and antiviral uses thereof

US6362171B1 · kind B1 · utility

Assignee

• Temple University-Of The Commonwealth System of Higher Education · US

Inventors

• Robert J. Suhadolnik · Roslyn, US
• Wolfgang Pfleiderer · Konstanz, DE

Key dates

• Filing date: Dec 9, 1999
• Grant date: Mar 26, 2002
• Expiry date: Dec 9, 2019

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K47/554
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Antiviral compounds and the water-soluble salts thereof have formula (I), wherein n is from 1 to 8; R1 is selected from the group consisting of (a), wherein m is zero, 1, 2 or 3; and (b), wherein q is from 1 to 20; R2 is independently selected from the group consisting of oxygen and sulfur; R3 is independently selected from the group consisting of hydrogen and hydroxyl; and R4 is selected from the group consisting of hydrogen, hydroxyl and (b); R5 is selected from the group consisting of hydroxyl and (b); R6 is selected from the group consisting of (c), (d) et (e), wherein x is from 1 to 20; provided that one of R1, R4 and R5 is (b) wherein R6 is defined as above; or water soluble salt thereof.