1, 2, 4-benzotriazine oxides as radiosensitizers and selective cytotoxic agents
US6362184B1 · kind B1 · utility
4Cited by
4References
7Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Oct 17, 1997 |
| Grant date | Mar 26, 2002 |
| Priority date | — |
| Expiry date | Oct 17, 2017 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D253/10
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A method of using 1,2,4-benzotriazine oxides, some of which are novel compounds, as radiosensitizers and selective cytotoxic agents is disclosed. These compounds are shown to specifically radiosensitive hypoxic tumor cells. Some are additionally disclosed to be useful as specific cytotoxic agents for these cells. They also show an unexpected ability to radiosensitize aerobic cells following or preceding a hypoxic incubation of the cells with the drug. This provides a basis for selective radiosensitization of tumors compared to normal cells. A novel method for preparing the 1,2,4-benzotriazine oxides is also disclosed.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.