Carboxylic acid amides, pharmaceutical compositions containing these compounds and their use

US6362210B1 · kind B1 · utility

Assignee

• BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG · DE

Inventors

• Norbert Hauel · Schemmerhofen, DE
• Henning Priepke · Warthausen, DE
• Klaus Damm · Meitingen, DE
• Andreas Schnapp · Biberach, DE

Key dates

• Filing date: Jul 18, 2000
• Grant date: Mar 26, 2002
• Expiry date: Jul 18, 2020

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02A50/30
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Carboxylic acid amides of general formula which inhibit telomerase and are useful for treating tumour diseases such as carcinomas, sarcomas and leukaemias. Exemplary compounds are:(1) trans-3-(naphth-2-yl)-but-2-enoic acid-N-(2-carboxy-phenyl)-amide, and,(2) trans-3-(naphth-2-yl)-but-2-enoic acid-N-(2-carboxy-4,5-dimethoxy-phenyl)-amide.