Brefeldin A derivatives
US6362218B1 · kind B1 · utility
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8Claims
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Assignee
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Key dates
| Filing date | Jun 16, 2000 |
| Grant date | Mar 26, 2002 |
| Priority date | — |
| Expiry date | Jun 16, 2020 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D315/00
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Cytotoxic Michael addition derivatives of brefeldin A are described. Oxidation of thiol addition products of brefeldin A provides the corresponding sulfoxides and sulfones. The sulfoxides exhibited more cytotoxic activity than the corresponding sulfides and sulfones in a variety of human cancer cell lines. Pharmaceutical formulations of the disclosed cytotoxic derivatives are also described.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.