Papillomavirus polyprotein constructs

US6365160B1 · kind B1 · utility

Assignees

• CSL LIMITED · AU
• The University Of Queensland · AU

Inventors

• Elizabeth Ann Webb · Melbourne, AU
• Mary Brigid Margetts · Melbourne, AU
• John C. Cox · Gisborne, AU
• Ian Frazer · Brisbane, AU
• Nigel Alan John McMillan · Brisbane, AU
• Mark Philip Williams · Brisbane, AU
• Margaret Bridget Holland Moloney · Melbourne, AU
• Stirling John Edwards · Melbourne, AU

Key dates

• Filing date: Apr 21, 1998
• Grant date: Apr 2, 2002
• Expiry date: Apr 21, 2018

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2710/20022
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Peptides, antibodies and recombinant expression systems or cells that contain and express a DNA insert of HPV encoding a region of a papilloma induced or a papilloma protein, such as E6 or E7, are produced. Compositions containing these peptides, antibodies and/or recombinant cells are utilized as immunogenic compositions and in methods for inhibiting and treating HPV infection and tumor initiation and progression. Specific peptides and recombinant cells, such as vaccinia virus and tumor cells, that express epitopic regions of the HPV16 E6 or E7 nucleoprotein are particularly described.