Gel formulations for topical drug delivery

US6365166B2 · kind B2 · utility

Assignee

• 3M INNOVATIVE PROPERTIES COMPANY · US

Inventors

• Joseph M. Beaurline · North St. Paul, US
• Patrick J. Roddy · Mahtomedi, US
• Mark A. Tomai · Woodbury, US

Key dates

• Filing date: Jun 4, 1999
• Grant date: Apr 2, 2002
• Expiry date: Jun 4, 2019

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K47/14
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Pharmaceutical gel formulations for topical drug delivery include drug, colloidal silicon dioxide, triacetin and, preferably, propylene glycol. The gel formulations are well suited for topical delivery of the drug 4-amino-2-ethoxymethyl-&agr;,&agr;-dimethyl-1H-imidazo[4,5-c]quinoline-1-ethanol, which when applied topically induces cytokines, such as interferon and tumor necrosis factor, locally in the skin or mucous membranes of a mammal. The gel formulations are also well-suited for topical delivery of drugs for treatment of diseases involving skin and/or mucosal lesions because the gel formulations do not need to include irritating components.