Method of making pressure sensitive adhesive matrix patches for transdermal drug delivery using hydrophilic salts of drugs and hydrophobic pressure sensitive adhesive dispersions
US6365178B1 · kind B1 · utility
56Cited by
5References
48Claims
0Family size
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Key dates
| Filing date | Jan 17, 2001 |
| Grant date | Apr 2, 2002 |
| Priority date | — |
| Expiry date | Jan 17, 2021 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K9/7061
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A method of making a pressure sensitive matrix patch for transdermal delivery of a drug is disclosed. The method includes the steps of dissolving a hydrophilic salt form of the drug in the water phase of an aqueous dispersion of a hydrophobic pressure sensitive adhesive, casting the resulting mixture as a thin film, and evaporating the water. The physical stability of the drug in the film is excellent, and crystallization of the drug is inhibited. A method of increasing the transdermal flux of an acidic drug is also disclosed.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.