Method for stereoselectively inverting a chiral center of a chemical compound using an enzyme and a metal catalyst
US6365380B2 · kind B2 · utility
6Cited by
8References
35Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jan 22, 2001 |
| Grant date | Apr 2, 2002 |
| Priority date | — |
| Expiry date | Jan 22, 2021 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12P41/002
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
A process for stereoselectively inverting a chiral center of a chemical compound is disclosed. The process first consists of forming a mixture of the chemical comopund, an enzymatic system, and a metal catalyst. Next, the process stereoselectively dehydrogenates a group attached to the chiral center with the enzymatic system in the presence of an oxidant to produce a dehydrogenated group, Lastly, the process hydrogenates the dehydrogenated group with the metal catalyst in the presence of a hydrogen source to stereoselectively invert the chiral center of the chemical compound.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.