S-substitute 11&bgr;-benzaldoxime-estra-4, 9-diene-carbonic acid thiolesters, method for the production thereof and pharmaceutical preparations containing these compounds

US6365582B1 · kind B1 · utility

Assignee

• Jenapharm GmbH & Co. KG · DE

Inventors

• Gerd Schubert · Jena, DE
• Sven Ring · Jena, DE
• Guenther Kaufmann · Jena, DE
• Walter Elger · Berlin, DE
• Birgit Schneider · Jena, DE

Key dates

• Filing date: Aug 22, 2000
• Grant date: Apr 2, 2002
• Expiry date: Aug 22, 2020

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07J43/006
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Thiol esters of S-substituted 11&bgr;-benzaldoxime-estra-4,9-dien-carboxylic acids of the formula I their pharmaceutically acceptable salts, a method for their synthesis and pharmaceutical preparations containing these compounds are described. These compounds bind to progesterone receptors and have distinctly reduced anti-glucocorticoid action.