Methods to enhance white blood cell count
US6365583B1 · kind B1 · utility
Assignee
Inventors
Key dates
| Filing date | Feb 1, 2000 |
| Grant date | Apr 2, 2002 |
| Priority date | — |
| Expiry date | Feb 1, 2020 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D401/10
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Methods to elevate white blood cell counts in animal subjects using compounds of formula (1) are disclosed. These compounds have the formulaZ-linker-Z′  (1)or pharmaceutically acceptable salt thereofwherein Z is a cyclic polyamine containing 9-32 ring members of which 3-8 are nitrogen atoms, said nitrogen atoms separated from each other by at least 2 carbon atoms, and wherein said heterocycle may optionally contain additional heteroatoms besides nitrogen and/or may be fused to an additional ring system;Z′ may be embodied in a form as defined by Z above, or alternatively may be of the formula—N(R)—(CR2)n—Xwherein each R is independently H or straight, branched or cyclic alkyl (1-6C), n is 1 or 2, and X is an aromatic ring, including heteroaromatic rings, or is a mercaptan;“linker” represents a bond, alkylene (1-6C) or may comprise aryl, fused aryl, oxygen atoms contained in an alkylene chain, or may contain keto groups or nitrogen or sulfur atoms;in an amount effective to elevate said WBC count in said subject.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.