Tricyclic amide and urea compounds useful for inhibition of G-protein function and for treatment of proliferative diseases

US6365588B1 · kind B1 · utility

Assignee

• SCHERING CORPORATION · US

Inventors

• Robert W. Bishop · Pequannock, US
• Ronald J. Doll · Maplewood, US
• Alan K. Mallams · Hackettstown, US
• F. George Njoroge · Hackettstown, US
• Joanne M. Petrin · Cedar Grove, US
• John J. Piwinski · Lebanon, US
• Ronald L. Wolin · San Diego, US
• Arthur G. Taveras · Rockaway, US
• Stacy Remiszewski · Hackettstown, US

Key dates

• Filing date: Jul 9, 1999
• Grant date: Apr 2, 2002
• Expiry date: Jul 9, 2019

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D417/14
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A method of inhibiting Ras function and therefore inhibiting the abnormal growth of cells is disclosed. The method comprises the administration of a compound of Formula 1.0: to a biological system. In particular, the method inhibits the abnormal growth of cells in a mammal such as a human being.Novel compounds of the formulas 5.0, 5.1 and 5.2, wherein R is —C(R20)(R21)(R46), and 5.3, 5.3A and 5.3B, wherein R is —N(R25)(R48), are disclosed.Also disclosed are processes for making 3-substituted compounds of Formulas 5.0, 5.1, 5.2 and 5.3.Further disclosed are novel compounds which are intermediates in the process for making 3-substituted compounds of Formulas 5.0, 5.1, 5.2 and 5.3.