Preparation of carboxylate-sulfonate polymers having cell proliferation-promoting properties

US6365692B1 · kind B1 · utility

Assignee

• Le Groupement d'Intérét Public Thérapeutiques Substitutives Institut Galilée, Université Paris-Nord · FR

Inventors

• Frank Hill · Mettmann, DE
• Peter Ottersbach · Windeck, DE
• Graciella Djavid · Paris, FR
• Marcel Jozefowicz · Persan, FR
• Veronique Migonney · Eaubonne, FR
• Jean-Pierre Vairon · Bourg-la-Reine, FR

Key dates

• Filing date: Dec 30, 1997
• Grant date: Apr 2, 2002
• Expiry date: Dec 30, 2017

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C08F228/00
• WIPO field: Medical technology
• WIPO sector: Instruments

Abstract

The invention relates to water-insoluble polymers which promote cell proliferation, contain carboxylate and sulfonate groups and are obtainable by free radical copolymerization of one or more aliphatically unsaturated monomers containing carboxylate groups, or the correspondingly functionalized derivatives of the monomers, as component I with one or more aliphatically unsaturated monomers containing sulfonate groups, or the correspondingly functionalized derivatives of the monomers, as component II and a component III which comprises an aliphatically unsaturated monomer or several aliphatically unsaturated monomers, the correspondingly functionalized derivatives being converted into carboxylate and sulfonate groups after the copolymerization, and to a process for their preparation, wherein the polymers are useful for forming articles which promote cell proliferation.