Methods and reagents for modulating TGF-&bgr; superfamily signalling
US6365711B1 · kind B1 · utility
11Cited by
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Key dates
| Filing date | May 28, 1998 |
| Grant date | Apr 2, 2002 |
| Priority date | — |
| Expiry date | May 28, 2018 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2333/495
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
FAST-1 and Smad2 or Smad3 form a complex that is specifically induced by signals generated by a TGF-&bgr; superfamily member. We have shown that a domain of FAST-1 directly interacts with Smad2 or Smad3, and that this interaction is mediated by specific domains of the two interacting molecules, namely, the MH2 domain of Smad2 or Smad3 and the Smad Interaction Domain (SID) of FAST-1. This result allows the development of methods and reagents for the isolation of compounds that are involved in, and/or modulate, TGF-&bgr; superfamily signalling.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.