Process for the preparation of 4,6-disubstituted 2-isocyanatopyrimidines and their use as intermediates for active compound syntheses

US6365739B1 · kind B1 · utility

Assignee

• Hoechst Schering Agrevo GmbH · DE

Inventors

• Mark James Ford · Nordenstadt, DE
• Stephen Lachhein · Hofheim, DE

Key dates

• Filing date: Jul 21, 1999
• Grant date: Apr 2, 2002
• Expiry date: Jul 21, 2019

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D239/545
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Isocyanates of the formula (I) in which X and Y are defined as in formula (I) of claim 1 can be prepared by reacting a compound of the formula (II) or its salts in which X and Y are defined as in formula (I),with 1 to 6 mol of phosgene per mole of compound of the formula (II), in the presence of 2 to 3.5 molar equivalents of a base per mole of compound of the formula (II) and in the presence of an aprotic organic solvent at a reaction temperature in the range from −30 to +60° C. to give the compound of the formula (I). The compounds (I) can be converted by reaction with nucleophiles to give addition products, such as carbamates, ureas and sulfonylureas and corresponding products, e.g. herbicidal sulfonylureas.