Compositions and methods for homoconjugates of antibodies which induce growth arrest or apoptosis of tumor cells
US6368596B1 · kind B1 · utility
78Cited by
4References
13Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jul 8, 1998 |
| Grant date | Apr 9, 2002 |
| Priority date | — |
| Expiry date | Jul 8, 2018 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2317/77
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
This invention discloses monoclonal antibodies (MAbs) which have little or no signaling activity as monomers become potent anti-tumor agents when they are converted into homoconjugates. The homoconjugates exert anti-growth activity by signaling G0/G1 arrest or apoptosis, depending upon which cell surface molecule they bind. This activity is specific and does not require an Fc portion. These conjugates are potent, anti-tumor agents.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.