Screening methods to identify inhibitors of telomerase activity
US6368789B1 · kind B1 · utility
22Cited by
5References
54Claims
0Family size
Inventors
Key dates
| Filing date | Jun 5, 1995 |
| Grant date | Apr 9, 2002 |
| Priority date | — |
| Expiry date | Jun 5, 2015 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10T436/115831
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Method and compositions are provided for the determination of telomere length and telomerase activity, as well as the ability to inhibit telomerase activity in the treatment of proliferative diseases. Particularly, primers are elongated under conditions which minimize interference from other genomic sequences, so as to obtain accurate determinations of telomeric length or telomerase activity. In addition, compositions are provided for intracellular inhibition of telomerase activity and means are shown for slowing the loss of telomeric repeats in aging cells.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.