Process for determining the agonist or antagonist of galanin receptor (GALR3)

US6368812B1 · kind B1 · utility

Assignee

• Synaptic Pharmaceutical Corporation · US

Inventors

• Jonathan Bard · New York, US
• Beth Borowsky · Montclair, US
• Kelli E. Smith · Wayne, US
• Theresa Branchek · Teaneck, US
• Christophe P. G. Gerald · Ridgewood, US
• Kenneth A. Jones · Bergenfield, US

Key dates

• Filing date: Apr 9, 1998
• Grant date: Apr 9, 2002
• Expiry date: Jun 8, 2018

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N2500/10
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

This invention provides an isolated nucleic acid encoding a mammalian galanin receptor, an isolated galanin receptor protein, vectors comprising isolated nucleic acid encoding a mammalian galanin receptor, cells comprising such vectors, antibodies directed to a mammalian galanin receptor, nucleic acid probes useful for detecting nucleic acid encoding a mammalian galanin receptor, antisense oligonucleotides complementary to unique sequences of nucleic acid encoding a mammalian galanin receptor, nonhuman transgenic animals which express DNA encoding a normal or a mutant mammalian galanin receptor, as well as methods of determining binding of compounds to mammalian galanin receptors.